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Article

Development of Mouse Hepatocyte Lines Permissive for Hepatitis C Virus (HCV)

22 Jun 2011

Abstract excerpt

The lack of a suitable small animal model for the analysis of hepatitis C virus (HCV) infection has hampered elucidation of the HCV life cycle and the development of both protective and therapeutic strategies against HCV infection. Human and mouse harbor a comparable system for antiviral type I interferon (IFN) induction and amplification, which regulates viral infection and replication. Using hepatocytes from...

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PMID: 21731692
DOI: 10.1371/journal.pone.0021284

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