Article
Phosphorylation of protein kinase Cdelta on distinct tyrosine residues induces sustained activation of Erk1/2 via down-regulation of MKP-1: role in the apoptotic effect of etoposide.
The Journal of biological chemistry - 20 Jun 2008
Lomonaco Stephanie L, Kahana Sarit, Blass Michal, Brody Yehuda, Okhrimenko Hana, Xiang Cunli, Finniss Susan, Blumberg Peter M, Lee Hae-Kyung, Brodie Chaya
Abstract excerpt
The mechanism underlying the important role of protein kinase Cdelta (PKCdelta) in the apoptotic effect of etoposide in glioma cells is incompletely understood. Here, we examined the role of PKCdelta in the activation of Erk1/2 by etoposide. We found that etoposide induced persistent activation of Erk1/2 and nuclear translocation of phospho-Erk1/2. MEK1 inhibitors decreased the apoptotic effect of etoposide,...
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