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Article

Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.

Molecular biology of the cell - 15 Apr 2011

Park Choon-Ho, Choi Bo-Hwa, Jeong Min-Woo, Kim Sangjune, Kim Wanil, Song Yun Seon, Kim Kyong-Tai

Abstract excerpt

Vaccinia-related kinase 1 (VRK1) is a novel serine/threonine kinase that plays an important role in cell proliferation. However, little is known about the upstream regulators of VRK1 activity. Here we provide evidence for a role of protein kinase Cδ (PKCδ) in the regulation of murine VRK1. We show that PKCδ interacts with VRK1, phosphorylates the Ser-355 residue in the putative regulatory region, and negatively...

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Source

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Identifiers

PMID: 21346188
DOI: 10.1091/mbc.E10-08-0717
PMCID: PMC3078082

Genes

VRK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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