Article
Protein kinase C zeta isoform is critical for proliferation in human glioblastoma cell lines.
Journal of neuro-oncology - 1 Apr 2000
Donson A M, Banerjee A, Gamboni-Robertson F, Fleitz J M, Foreman N K
Abstract excerpt
Previous studies have confirmed that proliferation in glioblastoma cell lines can be blocked by non-isoform specific protein kinase C (PKC) inhibitors, e.g calphostin C, staurosporine. However, the exact mechanism of PKC involvement is poorly understood. The aim of this study was to explore the role of specific PKC isoforms in the aberrant growth of glioblastoma. Identification of the isoform(s) critical for...
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