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Article

Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complex.

The Journal of biological chemistry - 26 Mar 2004

Kajimoto Taketoshi, Shirai Yasuhito, Sakai Norio, Yamamoto Toshiyoshi, Matsuzaki Hidenori, Kikkawa Ushio, Saito Naoaki

Abstract excerpt

Protein kinase C (PKC), a Ca(2+)/phospholipid-dependent protein kinase, is known as a key enzyme in various cellular responses, including apoptosis. However, the functional role of PKC in apoptosis has not been clarified. In this study, we focused on the involvement of PKCdelta in ceramide-induced apoptosis in HeLa cells and examined the importance of spatiotemporal activation of the specific PKC subtype in...

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PMID: 14715667
DOI: 10.1074/jbc.M312350200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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