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Article

Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.

The Journal of clinical investigation - 1 May 2008

Lim Jormay, Balastik Martin, Lee Tae Ho, Nakamura Kazuhiro, Liou Yih-Cherng, Sun Anyang, Finn Greg, Pastorino Lucia, Lee Virginia M-Y, Lu Kun Ping

Abstract excerpt

Tau pathology is a hallmark of many neurodegenerative diseases including Alzheimer disease (AD) and frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). Genetic tau mutations can cause FTDP-17, and mice overexpressing tau mutants such as P301L tau are used as AD models. However, since no tau mutations are found in AD, it remains unclear how appropriate tau mutant mice are as an AD model....

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Identifiers

PMID: 18431510
DOI: 10.1172/JCI34308
PMCID: PMC2323189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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