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Article

Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.

The Journal of biological chemistry - 15 Mar 2013

Kimura Taeko, Tsutsumi Koji, Taoka Masato, Saito Taro, Masuda-Suzukake Masami, Ishiguro Koichi, Plattner Florian, Uchida Takafumi, Isobe Toshiaki, Hasegawa Masato, Hisanaga Shin-Ichi

Abstract excerpt

Neurodegenerative diseases associated with the pathological aggregation of microtubule-associated protein Tau are classified as tauopathies. Alzheimer disease, the most common tauopathy, is characterized by neurofibrillary tangles that are mainly composed of abnormally phosphorylated Tau. Similar hyperphosphorylated Tau lesions are found in patients with frontotemporal dementia with parkinsonism linked to...

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Identifiers

PMID: 23362255
DOI: 10.1074/jbc.M112.433326
PMCID: PMC3597833

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Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites.PMID 23362255Read ↗

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