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Article

Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant Tau.

The Journal of biological chemistry - 19 Jun 2009

Yotsumoto Kensuke, Saito Taro, Asada Akiko, Oikawa Takayuki, Kimura Taeko, Uchida Chiyoko, Ishiguro Koichi, Uchida Takafumi, Hasegawa Masato, Hisanaga Shin-Ichi

Abstract excerpt

Neurodegenerative tauopathies, including Alzheimer disease, are characterized by abnormal hyperphosphorylation of the microtubule-associated protein Tau. One group of tauopathies, known as frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), is directly associated with mutations of the gene tau. However, it is unknown why mutant Tau is highly phosphorylated in the patient brain. In...

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Identifiers

PMID: 19401603
DOI: 10.1074/jbc.M109.003277
PMCID: PMC2719320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant Tau.PMID 19401603Read ↗

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