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Article

DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer's disease.

Neuroscience letters - 2 Dec 2005

Poli Maura, Gatta Luisa Benerini, Dominici Roberto, Lovati Carlo, Mariani Claudio, Albertini Alberto, Finazzi Dario

Abstract excerpt

Senile plaques and neurofibrillary tangles (NFT) are the prominent lesions in the brain of Alzheimer's disease (AD) patients. NFT are mainly composed of an abnormally phosphorylated form of tau protein, which has lost its function to bind microtubules and promote their assembly. Tau hyperphosphorylation critically decreases tau function and precedes neurodegeneration. The majority of tau phosphorylation sites are...

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Identifiers

PMID: 16095818
DOI: 10.1016/j.neulet.2005.07.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA sequence variations in the prolyl isomerase Pin1 gene and Alzheimer's disease.PMID 16095818Read ↗

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