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Article

Plasmacytoid dendritic cells in multiple sclerosis: intracerebral recruitment and impaired maturation in response to interferon-beta.

Journal of neuropathology and experimental neurology - 1 May 2008

Lande Roberto, Gafa Valérie, Serafini Barbara, Giacomini Elena, Visconti Andrea, Remoli Maria Elena, Severa Martina, Parmentier Marc, Ristori Giovanni, Salvetti Marco, Aloisi Francesca, Coccia Eliana Marina

Abstract excerpt

The roles of plasmacytoid dendritic cells (pDCs) and their response to interferon (IFN)-beta therapy in multiple sclerosis (MS) patients are poorly understood. We identified pDC accumulation in white matter lesions and leptomeninges of MS brains and abundant expression of the Type I IFN-induced protein MxA, mainly in perivascular CD3+ lymphocytes in lesions, indicating Type I IFN production by activated pDCs. The...

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PMID: 18431257
DOI: 10.1097/NEN.0b013e31816fc975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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