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Article

The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.

Brain : a journal of neurology - 1 Mar 2008

Ifergan Igal, Kébir Hania, Bernard Monique, Wosik Karolina, Dodelet-Devillers Aurore, Cayrol Romain, Arbour Nathalie, Prat Alexandre

Abstract excerpt

Trafficking of antigen-presenting cells into the CNS is essential for lymphocyte reactivation within the CNS compartment. Although perivascular dendritic cells found in inflammatory lesions are reported to polarize naive CD4+ T lymphocytes into interleukin-17-secreting-cells, the origin of those antigen-presenting cells remains controversial. We demonstrate that a subset of CD14+ monocytes migrate across the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18156156
DOI: 10.1093/brain/awm295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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