Article
Interferon-beta induces the development of type 2 dendritic cells.
Cytokine - 7 Mar 2001
Huang Y M, Hussien Y, Yarilin D, Xiao B G, Liu Y J, Link H
Abstract excerpt
Suppression of interleukin 12 (IL-12) production by dendritic cells (DCs) has been hypothesized to be a principal mechanism underlying the biological action of interferon (IFN)-beta used for treatment of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system with possible autoimmune origin. How IFN-beta interacts with DCs to inhibit IL-12 production remains unclear. In this study,...
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