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Article

<i>Bromodomain 4</i> activation predicts breast cancer survival

22 Apr 2008

Abstract excerpt

Previous work identified the Rap1 GTPase-activating protein Sipa1 as a germ-line-encoded metastasis modifier. The bromodomain protein Brd4 physically interacts with and modulates the enzymatic activity of Sipa1. In vitro analysis of a highly metastatic mouse mammary tumor cell line ectopically expressing Brd4 demonstrates significant reduction of invasiveness without altering intrinsic growth rate. However, a...

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PMID: 18427120
DOI: 10.1073/pnas.0710331105

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