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Article

BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 Signaling

20 Sept 2016

Abstract excerpt

The bromodomain and extraterminal (BET) proteins are epigenetic "readers" of acetylated histones in chromatin and have been identified as promising therapeutic targets in diverse cancers. However, it remains unclear how individual family members participate in cancer progression and small molecule inhibitors such as JQ1 can target functionally independent BET proteins. Here, we report a signaling pathway...

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PMID: 27651315
DOI: 10.1158/0008-5472.can-16-0559

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