Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytotoxic T-lymphocyte escape mutations identified by HLA association favor those which escape and revert rapidly.

Journal of virology - 1 Aug 2012

Fryer Helen R, Frater John, Duda Anna, Palmer Duncan, Phillips Rodney E, McLean Angela R

Abstract excerpt

Identifying human immunodeficiency virus (HIV) immune escape mutations has implications for understanding the impact of host immunity on pathogen evolution and guiding the choice of vaccine antigens. One means of identifying cytotoxic-T-lymphocyte (CTL) escape mutations is to search for statistical associations between mutations and host human leukocyte antigen (HLA) class I alleles at the population level. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epitopes, T-Lymphocyte
Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Infections

Share to Models, Theoretical

Share to Phylogeny

Share to T-Lymphocytes, Cytotoxic

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22674992
DOI: 10.1128/JVI.07020-11
PMCID: PMC3421756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytotoxic T-lymphocyte escape mutations identified by HLA association favor those which escape and revert rapidly.PMID 22674992Read ↗

Modelling the evolution and spread of HIV immune escape mutants.Semantic proximity Read ↗

Inferring HIV Escape Rates from Multi-Locus Genotype DataSemantic proximity Read ↗

Modelling the spread of HIV immune escape mutants in a vaccinated population.Semantic proximity Read ↗

The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLA-associated risk of AIDS progression.Semantic proximity Read ↗

Rates of HIV immune escape and reversion: implications for vaccination.Semantic proximity Read ↗

HLA-Associated Clinical Progression Correlates with Epitope Reversion Rates in Early Human Immunodeficiency Virus InfectionSemantic proximity Read ↗

Relative rate and location of intra-host HIV evolution to evade cellular immunity are predictableSemantic proximity Read ↗

The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations.Semantic proximity Read ↗

Marked epitope- and allele-specific differences in rates of mutation in human immunodeficiency type 1 (HIV-1) Gag, Pol, and Nef cytotoxic T-lymphocyte epitopes in acute/early HIV-1 infection.Semantic proximity Read ↗

Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1.Semantic proximity Read ↗

Computational inference methods for selective sweeps arising in acute HIV infection.Semantic proximity Read ↗

Reversion of immune escape HIV variants upon transmission: insights into effective viral immunity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.