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Article

Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity.

Diabetes - 1 Jul 2008

Féral Chloé C, Neels Jaap G, Kummer Christiane, Slepak Marina, Olefsky Jerrold M, Ginsberg Mark H

Abstract excerpt

OBJECTIVE: Many prevalent diseases of advanced societies, such as obesity-induced type 2 diabetes, are linked to indolent mononuclear cell-dependent inflammation. We previously proposed that blockade of alpha4 integrin signaling can inhibit inflammation while limiting mechanism-based toxicities of loss of alpha4 function. Thus, we hypothesized that mice bearing an alpha4(Y991A) mutation, which blocks signaling,...

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Identifiers

PMID: 18426864
DOI: 10.2337/db07-1751
PMCID: PMC2453617

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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