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Article

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

3 Feb 2014

Abstract excerpt

The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF receptor-associated factors (TRAFs), in diet-induced obesity (DIO). Although not exhibiting increased weight gain, male CD40(-/-) mice in DIO displayed worsened insulin resistance, compared with wild-type mice. This worsening was...

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PMID: 24492375
DOI: 10.1073/pnas.1400419111

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