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Article

Macrophage beta3 integrin suppresses hyperlipidemia-induced inflammation by modulating TNFalpha expression.

Arteriosclerosis, thrombosis, and vascular biology - 1 Dec 2007

Schneider Jochen G, Zhu Yimin, Coleman Trey, Semenkovich Clay F

Abstract excerpt

OBJECTIVE: High-fat, cholesterol-containing diets contribute to hyperlipidemia. Both high-fat diets and hyperlipidemia are associated with chronic inflammatory diseases like atherosclerosis. Integrins, heterodimeric mediators of inflammatory cell recruitment, are not generally thought to be affected by diet. However, high-fat feeding promotes inflammation, atherosclerosis, and death in hyperlipidemic mice with...

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Identifiers

PMID: 17951320
DOI: 10.1161/ATVBAHA.107.153650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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