Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO).

doi:10.1160/TH16-07-0553

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Article

Inflammation, but not recruitment, of adipose tissue macrophages requires signalling through Mac-1 (CD11b/CD18) in diet-induced obesity (DIO).

Thrombosis and haemostasis - 26 Jan 2017

Wolf Dennis, Bukosza Nora, Engel David, Poggi Marjorie, Jehle Felix, Anto Michel Nathaly, Chen Yung-Chih, Colberg Christian, Hoppe Natalie, Dufner Bianca, Boon Louis, Blankenbach Hermann, Hilgendorf Ingo, von Zur Muhlen Constantin, Reinöhl Jochen, Sommer Björn, Marchini Timoteo, Febbraio Mark A, Weber Christian, Bode Christoph, Peter Karlheinz, Lutgens Esther, Zirlik Andreas

Abstract excerpt

Cell accumulation is a prerequisite for adipose tissue inflammation. The leukocyte integrin Mac-1 (CD11b/CD18, αMβ2) is a classic adhesion receptor critically regulating inflammatory cell recruitment. Here, we tested the hypothesis that a genetic deficiency and a therapeutic modulation of Mac-1 regulate adipose tissue inflammation in a mouse model of diet-induced obesity (DIO). C57Bl6/J mice genetically deficient...

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PMID: 27853810
DOI: 10.1160/TH16-07-0553

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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