Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity.

Diabetes - 1 Dec 2012

Macia Laurence, Yulyaningsih Ernie, Pangon Laurent, Nguyen Amy D, Lin Shu, Shi Yan C, Zhang Lei, Bijker Martijn, Grey Shane, Mackay Fabienne, Herzog Herbert, Sainsbury Amanda

Abstract excerpt

Recruitment of activated immune cells into white adipose tissue (WAT) is linked to the development of insulin resistance and obesity, but the mechanism behind this is unclear. Here, we demonstrate that Y1 receptor signaling in immune cells controls inflammation and insulin resistance in obesity. Selective deletion of Y1 receptors in the hematopoietic compartment of mice leads to insulin resistance and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Chemokine CCL2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dietary Fats

Share to Eating

Share to Inflammation

Share to Insulin Resistance

Share to Receptors, Neuropeptide Y

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 23011592
DOI: 10.2337/db12-0156
PMCID: PMC3501846

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity.PMID 23011592Read ↗

Macrophage function in obesity-induced inflammation and insulin resistanceSemantic proximity Read ↗

Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis.Semantic proximity Read ↗

Adipose Tissue Macrophage Phenotypes and Characteristics: The Key to Insulin Resistance in Obesity and Metabolic Disorders.Semantic proximity Read ↗

MicroRNAs Control Macrophage Formation and Activation: The Inflammatory Link between Obesity and Cardiovascular DiseasesSemantic proximity Read ↗

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.Semantic proximity Read ↗

Obesity, innate immunity and gut inflammation.Semantic proximity Read ↗

mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function.Semantic proximity Read ↗

Adipose tissue macrophages: their role in adipose tissue remodeling.Semantic proximity Read ↗

B Lymphocytes and Adipose Tissue Inflammation.Semantic proximity Read ↗

Adipose tissue recruitment of leukocytes.Semantic proximity Read ↗

IRE1 gives weight to obesity-associated inflammationSemantic proximity Read ↗

Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.