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Article

Impact of genetic polymorphisms in ABCB1, CYP2B6, OPRM1, ANKK1 and DRD2 genes on methadone therapy in Han Chinese patients.

Pharmacogenomics - 1 Nov 2011

Hung Chin-Chuan, Chiou Mu-Han, Huang Bo-Hau, Hsieh Yow-Wen, Hsieh Tsung-Jen, Huang Chieh-Liang, Lane Hsien-Yuan

Abstract excerpt

AIM: The present study explored the integrative effect of genes encoding methadone pharmacokinetic and pharmacodynamic pathways on methadone maintenance doses in Han Chinese Patients. MATERIALS & METHODS: Genomic DNA was extracted from 321 opioid-dependent patients and 202 healthy controls, and realtime-PCR and PCR-RFLP were conducted to determine the genotypes. RESULTS: Pair-wise comparisons revealed that...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

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Share to Oxidoreductases, N-Demethylating

Share to Receptors, Dopamine D2

Share to Receptors, Opioid, mu

Source

Identifiers

PMID: 21902500
DOI: 10.2217/pgs.11.96

Genes

ABCB1
DRD2
OPRM1

Provenance

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