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Article

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH.

Chemistry & biology - 1 Apr 2008

Sachdeva Sarbjot, Musayev Faik N, Alhamadsheh Mamoun M, Scarsdale J Neel, Wright H Tonie, Reynolds Kevin A

Abstract excerpt

Mycobacterium tuberculosis FabH initiates type II fatty acid synthase-catalyzed formation of the long chain (C(16)-C(22)) acyl-coenzyme A (CoA) precursors of mycolic acids, which are major constituents of the bacterial cell envelope. Crystal structures of M. tuberculosis FabH (mtFabH) show the substrate binding site to be a buried, extended L-shaped channel with only a single solvent access portal. Entrance of an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18420147
DOI: 10.1016/j.chembiol.2008.03.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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