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Article

Substrate recognition by β-ketoacyl-ACP synthases.

Biochemistry - 13 Dec 2011

Borgaro Janine G, Chang Andrew, Machutta Carl A, Zhang Xujie, Tonge Peter J

Abstract excerpt

β-Ketoacyl-ACP synthase (KAS) enzymes catalyze Claisen condensation reactions in the fatty acid biosynthesis pathway. These reactions follow a ping-pong mechanism in which a donor substrate acylates the active site cysteine residue after which the acyl group is condensed with the malonyl-ACP acceptor substrate to form a β-ketoacyl-ACP. In the priming KASIII enzymes the donor substrate is an acyl-CoA while in the...

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Identifiers

PMID: 22017312
DOI: 10.1021/bi201199x
PMCID: PMC3361727

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