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Article

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation.

eLife - 7 Sept 2021

Patil Gajanan S, Kinatukara Priyadarshan, Mondal Sudipta, Shambhavi Sakshi, Patel Ketan D, Pramanik Surabhi, Dubey Noopur, Narasimhan Subhash, Madduri Murali Krishna, Pal Biswajit, Gokhale Rajesh S, Sankaranarayanan Rajan

Abstract excerpt

Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes. They do so by bypassing the ubiquitous coenzyme A-dependent activation and rely on the acyl carrier protein-tethered 4'-phosphopantetheine (holo-ACP). The molecular basis of how FAALs strictly reject...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 34490847
DOI: 10.7554/eLife.70067
PMCID: PMC8460268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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