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Article

A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites.

Nature structural & molecular biology - 1 Sept 2004

Sankaranarayanan Rajan, Saxena Priti, Marathe Uttara B, Gokhale Rajesh S, Shanmugam Vellaiah M, Rukmini Raju

Abstract excerpt

The superfamily of plant and bacterial type III polyketide synthases (PKSs) produces diverse metabolites with distinct biological functions. PKS18, a type III PKS from Mycobacterium tuberculosis, displays an unusual broad specificity for aliphatic long-chain acyl-coenzyme A (acyl-CoA) starter units (C(6)-C(20)) to produce tri- and tetraketide pyrones. The crystal structure of PKS18 reveals a 20 A substrate...

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PMID: 15286723
DOI: 10.1038/nsmb809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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