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Article

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity.

The Journal of biological chemistry - 16 Sept 2005

Brown Alistair K, Sridharan Sudharsan, Kremer Laurent, Lindenberg Sandra, Dover Lynn G, Sacchettini James C, Besra Gurdyal S

Abstract excerpt

Mycolic acids are the dominant feature of the Mycobacterium tuberculosis cell wall. These alpha-alkyl, beta-hydroxy fatty acids are formed by the condensation of two fatty acids, a long meromycolic acid and a shorter C(24)-C(26) fatty acid. The component fatty acids are produced via a combination of type I and II fatty acid synthases (FAS) with FAS-I products being elongated by FAS-II toward meromycolic acids....

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Identifiers

PMID: 16040614
DOI: 10.1074/jbc.M413216200

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FAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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