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Article

Structural Basis for the Strict Substrate Selectivity of the Mycobacterial Hydrolase LipW.

Biochemistry - 27 Dec 2016

McKary Magy G, Abendroth Jan, Edwards Thomas E, Johnson R Jeremy

Abstract excerpt

The complex life cycle of Mycobacterium tuberculosis requires diverse energy mobilization and utilization strategies facilitated by a battery of lipid metabolism enzymes. Among lipid metabolism enzymes, the Lip family of mycobacterial serine hydrolases is essential to lipid scavenging, metabolic cycles, and reactivation from dormancy. On the basis of the homologous rescue strategy for mycobacterial drug targets,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27936614
DOI: 10.1021/acs.biochem.6b01057
PMCID: PMC5482207

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