Article
Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein.
Journal of virology - 1 Jul 2008
Machida Keigo, Kondo Yasuteru, Huang Jeffrey Y, Chen Yung-Chia, Cheng Kevin T-H, Keck Zhenyong, Foung Steven, Dubuisson Jean, Sung Vicky M-H, Lai Michael M C
Abstract excerpt
Hepatitis C virus (HCV) often causes persistent infection despite the presence of neutralizing antibodies against the virus in the sera of hepatitis C patients. HCV infects both hepatocytes and B cells through the binding of its envelope glycoprotein E2 to CD81, the putative viral receptor. Previously, we have shown that E2-CD81 interaction induces hypermutation of heavy-chain immunoglobulin (V(H)) in B cells. We...
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