Article
Mutations in hepatitis C virus E2 located outside the CD81 binding sites lead to escape from broadly neutralizing antibodies but compromise virus infectivity.
Journal of virology - 1 Jun 2009
Keck Zhen-yong, Li Sophia H, Xia Jinming, von Hahn Thomas, Balfe Peter, McKeating Jane A, Witteveldt Jeroen, Patel Arvind H, Alter Harvey, Rice Charles M, Foung Steven K H
Abstract excerpt
Broadly neutralizing antibodies are commonly present in the sera of patients with chronic hepatitis C virus (HCV) infection. To elucidate possible mechanisms of virus escape from these antibodies, retrovirus particles pseudotyped with HCV glycoproteins (HCVpp) isolated from sequential samples collected over a 26-year period from a chronically infected patient, H, were used to characterize the neutralization...
Topics
- Amino Acid Substitution
- Antibodies, Monoclonal
- Antibody Affinity
- Antigens, CD
- Binding Sites
- Cell Line
- Epitopes
- Hepacivirus
- Hepatitis C
- Hepatitis C Antibodies
- Humans
- Mutagenesis, Site-Directed
- Mutation