Article
Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
Gastroenterology - 1 Jul 2012
Fofana Isabel, Fafi-Kremer Samira, Carolla Patric, Fauvelle Catherine, Zahid Muhammad Nauman, Turek Marine, Heydmann Laura, Cury Karine, Hayer Juliette, Combet Christophe, Cosset François-Loïc, Pietschmann Thomas, Hiet Marie-Sophie, Bartenschlager Ralf, Habersetzer François, Doffoël Michel, Keck Zhen-Yong, Foung Steven K H, Zeisel Mirjam B, Stoll-Keller Françoise, Baumert Thomas F
Abstract excerpt
BACKGROUND & AIMS: The development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; this process involves several viral and host factors and is targeted by host-neutralizing responses. Although the roles of host factors in HCV entry have been well characterized, their involvement in evasion of immune...
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