Article
Mutations within a conserved region of the hepatitis C virus E2 glycoprotein that influence virus-receptor interactions and sensitivity to neutralizing antibodies.
Journal of virology - 1 Jun 2010
Dhillon Simrat, Witteveldt Jeroen, Gatherer Derek, Owsianka Ania M, Zeisel Mirjam B, Zahid Muhammad N, Rychłowska Malgorzata, Foung Steven K H, Baumert Thomas F, Angus Allan G N, Patel Arvind H
Abstract excerpt
Cell culture-adaptive mutations within the hepatitis C virus (HCV) E2 glycoprotein have been widely reported. We identify here a single mutation (N415D) in E2 that arose during long-term passaging of HCV strain JFH1-infected cells. This mutation was located within E2 residues 412 to 423, a highly conserved region that is recognized by several broadly neutralizing antibodies, including the mouse monoclonal...
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