Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.

doi:10.1038/s41423-020-0403-1

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Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.

Cellular & molecular immunology - 1 Mar 2021

Yi Chunyan, Xia Jing, He Lan, Ling Zhiyang, Wang Xuesong, Yan Yu, Wang Jiangjun, Zhao Xinhao, Fan Weiguo, Sun Xiaoyu, Zhang Ronghua, Ye Sheng, Zhang Rongguang, Xu Yongfen, Ma Liyan, Zhang Yaguang, Zhou Honglin, Huang Zhong, Niu Junqi, Long Gang, Lu Junxia, Zhong Jin, Sun Bing

Abstract excerpt

Induction of broadly neutralizing monoclonal antibodies (bNAbs) that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus (HCV) vaccine research. The study of bNAbs arising in natural infection is essential in this endeavor. We generated a human antibody, 8D6, recognizing the E2 protein of HCV isolated from a chronic hepatitis C patient. This antibody shows broadly neutralizing activity,...

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PMID: 32235917
DOI: 10.1038/s41423-020-0403-1
PMCID: PMC7222171

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