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Article

Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding.

Journal of virology - 1 Sept 2006

Owsianka Ania M, Timms Judith M, Tarr Alexander W, Brown Richard J P, Hickling Timothy P, Szwejk Aleksandra, Bienkowska-Szewczyk Krystyna, Thomson Brian J, Patel Arvind H, Ball Jonathan K

Abstract excerpt

Hepatitis C virus (HCV) cell entry involves interaction between the viral envelope glycoprotein E2 and the cell surface receptor CD81. Knowledge of conserved E2 determinants important for successful binding will facilitate development of entry inhibitors designed to block this interaction. Previous studies have assigned the CD81 binding function to a number of discontinuous regions of E2. To better define...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16912317
DOI: 10.1128/JVI.00271-06
PMCID: PMC1563869

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of conserved residues in the E2 envelope glycoprotein of the hepatitis C virus that are critical for CD81 binding.PMID 16912317Read ↗

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