Article

Structural determinants for GqPCR-mediated inhibition of TASK K2P K <sup>+</sup> channels and their dysfunction in disease

2025-08-05

Abstract excerpt

Two-Pore Domain K + (K2P) channels are crucial determinants of cellular electrical excitability. TASK-1 and TASK-3 K2P channels regulate the resting membrane potential in many different cell types where their activity is also coupled to GqPCR signalling pathways via direct inhibition by diacylglycerol (DAG) generated as a result of phosphatidylinositol-4,5-bisphosphate (PIP 2 ) hydrolysis. This regulation is def...

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Literature Corpus work: 54a01c06-cb5e-552d-9f99-80f8837059fe
DOI: 10.1101/2025.08.04.668454

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