Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus.

doi:10.7554/eLife.85317

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Article

Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus.

eLife - 13 Apr 2023

Teng Bochuan, Kaplan Joshua P, Liang Ziyu, Chyung Kevin Saejin, Goldschen-Ohm Marcel P, Liman Emily R

Abstract excerpt

Otopetrin proteins (OTOPs) form proton-selective ion channels that are expressed in diverse cell types where they mediate detection of acids or regulation of pH. In vertebrates there are three family members: OTOP1 is required for formation of otoconia in the vestibular system and it forms the receptor for sour taste, while the functions of OTOP2 and OTOP3 are not yet known. Importantly, the gating mechanisms of...

Topics

Animals
Mice
Protons
Zinc
Vertebrates
Acids
Mutation
Membrane Proteins

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PMID: 37053086
DOI: 10.7554/eLife.85317
PMCID: PMC10101688

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