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Article

Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels.

Scientific reports - 22 Jan 2016

Goldstein Matthias, Rinné Susanne, Kiper Aytug K, Ramírez David, Netter Michael F, Bustos Daniel, Ortiz-Bonnin Beatriz, González Wendy, Decher Niels

Abstract excerpt

Two-pore-domain potassium (K2P) channels have a large extracellular cap structure formed by two M1-P1 linkers, containing a cysteine for dimerization. However, this cysteine is not present in the TASK-1/3/5 subfamily. The functional role of the cap is poorly understood and it remained unclear whether K2P channels assemble in the domain-swapped orientation or not. Functional alanine-mutagenesis screens of TASK-1...

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Identifiers

PMID: 26794006
DOI: 10.1038/srep19492
PMCID: PMC4726246

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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