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Article

The putative tumor suppressor AIM2 is frequently affected by different genetic alterations in microsatellite unstable colon cancers.

Genes, chromosomes & cancer - 1 Dec 2007

Woerner Stefan M, Kloor Matthias, Schwitalle Yvette, Youmans Hanni, Doeberitz Magnus von Knebel, Gebert Johannes, Dihlmann Susanne

Abstract excerpt

Mismatch repair (MMR) deficiency is a major mechanism of colorectal tumorigenesis that is observed in 10-15% of sporadic colorectal cancers and those associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. MMR deficiency leads to the accumulation of mutations mainly at short repetitive sequences termed microsatellites, constituting the high level microsatellite instability (MSI-H)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17726700
DOI: 10.1002/gcc.20493

Genes

AIM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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