Article
Background mutation frequency in microsatellite-unstable colorectal cancer.
Cancer research - 15 Jun 2007
Sammalkorpi Heli, Alhopuro Pia, Lehtonen Rainer, Tuimala Jarno, Mecklin Jukka-Pekka, Järvinen Heikki J, Jiricny Josef, Karhu Auli, Aaltonen Lauri A
Abstract excerpt
Microsatellite instability (MSI) is observed in approximately 12% of colorectal cancers. Genes containing a mononucleotide microsatellite in the coding sequence are particularly prone to inactivation in MSI tumorigenesis, and much work has been conducted to identify genes with high repetitive tract mutation rates in these tumors. Much less attention has been paid to background mutation frequencies, and no work...
Topics
- Colorectal Neoplasms
- DNA Mutational Analysis
- DNA, Neoplasm
- Humans
- Microsatellite Instability
- Mutation
- Polymerase Chain Reaction
- Repetitive Sequences, Nucleic Acid