Article
Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers.
Cancer research - 1 Jun 2005
Hienonen Tuija, Sammalkorpi Heli, Enholm Susa, Alhopuro Pia, Barber Thomas D, Lehtonen Rainer, Nupponen Nina N, Lehtonen Heli, Salovaara Reijo, Mecklin Jukka-Pekka, Järvinen Heikki, Koistinen Riitta, Arango Diego, Launonen Virpi, Vogelstein Bert, Karhu Auli, Aaltonen Lauri A
Abstract excerpt
DNA mismatch repair (MMR)-deficient cells typically accumulate mutations in short repetitive DNA tracts. This microsatellite instability (MSI) facilitates malignant transformation when affecting genes with growth-related and caretaker functions. To date, several putative MSI target genes have been proposed mainly based on high mutation frequency within their coding regions. However, some intronic repeat mutations...
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