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Article

Mutational targets in colorectal cancer cells with microsatellite instability.

Familial cancer - 1 Jan 2006

Bertholon Jacques, Wang Qing, Galmarini Carlos Maria, Puisieux Alain

Abstract excerpt

Cancers arise from the sequential acquisition of genetic alterations in specific genes. The high number of mutations in cancer cells led to the hypothesis that an early step in tumor progression is the generation of a genetic instability. The potent role of genetic instability in initiation and progression of colorectal cancers has been well defined in hereditary nonpolyposis colon cancer (HNPCC) syndrome. HNPCC...

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PMID: 16528606
DOI: 10.1007/s10689-005-2573-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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