Article
The serotonin transporter genotype is associated with intermediate brain phenotypes that depend on the context of eliciting stressor.
Molecular psychiatry - 1 Nov 2008
Kalin N H, Shelton S E, Fox A S, Rogers J, Oakes T R, Davidson R J
Abstract excerpt
A variant allele in the promoter region of the serotonin transporter gene, SLC6A4, the s allele, is associated with increased vulnerability to develop anxiety-related traits and depression. Furthermore, functional magnetic resonance imaging (fMRI) studies reveal that s carriers have increased amygdala reactivity in response to aversive stimuli, which is thought to be an intermediate phenotype mediating the...
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