Article
Serotonin transporter gene alters insula activity to threat in social anxiety disorder.
Neuroreport - 20 Aug 2014
Klumpp Heide, Fitzgerald Daniel A, Cook Edwin, Shankman Stewart A, Angstadt Mike, Phan K Luan
Abstract excerpt
Amygdala and insula hyper-reactivity to threat is implicated in social anxiety disorder (SAD) yet inconsistencies in activation have been reported. One source of variance are individual differences in 5-HTTLPR genotype where the short (S), relative to long (L) allele, corresponds with greater amygdala activation. However, the impact of genotype on insula to threat in SAD is not known. During functional MRI, 34...
Topics
- Adolescent
- Adult
- Amygdala
- Anxiety Disorders
- Brain Mapping
- Cerebral Cortex
- Emotions
- Face
- Facial Expression
- Female
- Genotype
- Genotyping Techniques
- Humans
- Magnetic Resonance Imaging
- Male