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Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET.

NeuroImage - 1 Oct 2009

Christian B T, Fox A S, Oler J A, Vandehey N T, Murali D, Rogers J, Oakes T R, Shelton S E, Davidson R J, Kalin N H

Abstract excerpt

UNLABELLED: The length polymorphism of the serotonin (5-HT) transporter gene promoter region has been implicated in altered 5-HT function and, in turn, neuropsychiatric illnesses, such as anxiety and depression. The nonhuman primate has been used as a model to study anxiety-related mechanisms in humans based upon similarities in behavior and the presence of a similar 5-HT transporter gene polymorphism. Stressful...

Topics

Aniline Compounds
Animals
Brain
Carbon Radioisotopes
Female
Genotype
Humans
Macaca mulatta
Male
Positron-Emission Tomography
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radiopharmaceuticals

Serotonin Plasma Membrane Transport Proteins

Sulfides

Tissue Distribution

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Identifiers

PMID: 19505582
DOI: 10.1016/j.neuroimage.2009.05.090
PMCID: PMC2798593

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