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Article

Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter.

Nature neuroscience - 1 Jan 2005

Heinz Andreas, Braus Dieter F, Smolka Michael N, Wrase Jana, Puls Imke, Hermann Derik, Klein Sabine, Grüsser Sabine M, Flor Herta, Schumann Gunter, Mann Karl, Büchel Christian

Abstract excerpt

Major depression is conditionally linked to a polymorphism of the human serotonin transporter gene (SLC6A4). During the presentation of aversive, but not pleasant, pictures, healthy carriers of the SLC6A4 short (s) allele showed stronger activation of the amygdala on functional magnetic resonance imaging. s carriers also showed greater coupling between the amygdala and the ventromedial prefrontal cortex, which...

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PMID: 15592465
DOI: 10.1038/nn1366

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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