Article
Serotonin transporter genotype modulates amygdala activity during mood regulation.
Social cognitive and affective neuroscience - 1 Mar 2010
Gillihan Seth J, Rao Hengyi, Wang Jiongjiong, Detre John A, Breland Jessica, Sankoorikal Geena Mary V, Brodkin Edward S, Farah Martha J
Abstract excerpt
Recent studies have implicated the short allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) in depression vulnerability, particularly in the context of stress. Several neuroimaging studies have shown that 5-HTTLPR genotype predicts amygdala reactivity to negatively valenced stimuli, suggesting a mechanism whereby the short allele confers depression risk. The current study investigated...
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