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Article

p53: A new player in reproduction

1 Apr 2008

Abstract excerpt

The roles of the p53 protein in tumor suppression have been firmly established. However, the functions of this protein under normal conditions or in the absence of stress, if any, have remained a mystery. In humans, some alleles containing a functional single nucleotide polymorphism in the p53 gene and its negative regulator, the Mdm2 gene, are under positive selection over evolutionary time frames, suggesting...

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PMID: 18414047
DOI: 10.4161/cc.7.7.5658

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