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Article

p53 regulates maternal reproduction through LIF.

Nature - 29 Nov 2007

Hu Wenwei, Feng Zhaohui, Teresky Angelika K, Levine Arnold J

Abstract excerpt

Extensive studies have shown that p53 is important in tumour prevention. However, little is known about its normal physiological function. Here we show that p53 is important in reproduction, in a gender-specific manner. Significant decreases in embryonic implantation, pregnancy rate and litter size were observed in matings with p53-/- female mice but not with p53-/- male mice. The gene encoding leukaemia...

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Source

Identifiers

PMID: 18046411
DOI: 10.1038/nature05993

Genes

LIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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