Article
Regulation of female reproduction by p53 and its family members.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 2011
Feng Zhaohui, Zhang Cen, Kang Hey-Joo, Sun Yvonne, Wang Haijian, Naqvi Asad, Frank Amanda K, Rosenwaks Zev, Murphy Maureen E, Levine Arnold J, Hu Wenwei
Abstract excerpt
Tumor suppressor p53 is crucial for embryonic implantation through transcriptional up-regulation of uterine leukemia inhibitory factor (LIF). This article reports that p53 and estrogen receptor α were activated in endometrial tissues during implantation to coordinately regulate LIF production. By using human p53 knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline),...
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