Article
Study of p53 gene mutations and placental expression in recurrent miscarriage cases.
Reproductive biomedicine online - 1 Mar 2009
Kaare Milja, Bützow Ralf, Ulander Veli-Matti, Kaaja Risto, Aittomäki Kristiina, Painter Jodie N
Abstract excerpt
This study aimed to investigate the role of p53 in early human development by screening patients with recurrent miscarriages (RM) for mutations in the p53 gene and by studying p53 expression in placental tissue. A total of 46 women with RM and 191 control women were included in the study. A sample was also obtained from 40 male partners of RM patients. The samples were screened for p53 sequence variations using...
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