Article
Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss.
European journal of obstetrics, gynecology, and reproductive biology - 1 Nov 2014
Fraga Lucas R, Boquett Juliano A, Dutra Caroline G, Vianna Fernanda S, Heck Camila, Gonçalves Rozana O, Paskulin Diego D, Costa Olívia L, Ashton-Prolla Patrícia, Sanseverino Maria Teresa V, Schuler-Faccini Lavínia
Abstract excerpt
OBJECTIVE: Recent studies have investigated the role of the p53 gene family in reproductive processes. Each member of the gene family acts through different mechanisms: p53 is involved in genomic stability and regulation of blastocyst implantation; p63 acts as a regulator of the quality and maturation of oocytes; and p73 controls the meiotic spindle. Polymorphisms in the genes of the p53 family have been...
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